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KMID : 0608520080140030057
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Korean Journal of Oriental Medicine
2008 Volume.14 No. 3 p.57 ~ p.63
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The Effects of Glehnia littoralis on the Inflammatory mediators in Mouse Macrophage Cells
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Yoon Tae-sook
Lee A-Young
Choo Byung-kil
Moon Byeong-cheol
Kim Ho-kyoung
Cheon Myeong-Sook
Kim Seung-Ju
Choi Goya
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Abstract
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Glennie littoralis (Umbelliferae) is the medicinal plant used traditionally for treatment of immune-related diseases. Prostaglandins and nitric oxide (NO) have been implicated as important mediators in the processes of inflammation and carcinogenesis. For understanding the mechanisms for pharmacological activities of Glehnia littoralis, we evaluated the inhibitory activity of Glehnia littoralis on lipopolysaccharide (LPS)-induced prostaglandin E₂ (PGE2) and NO production in mouse macrophage RAW264.7 cells. The results showed that the extract of Glehnia littoralis inhibited LPS-induced PGE₂ production effectively, but not NO. Additional study revealed that the extract of Glehnia littoralis suppressed cyclooxygenase-2 (COX-2) expression in a dose-dependent manner. Present study suggests that Clehnia Iittorslis may have anti-inflammatory and/or cancer chemopreventive activity through the inhibition of PGE₂ production by the suppression of COX-2 activity.
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KEYWORD
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Glehnia littoralis, Anti-inflammation, Cancer chemoprevention, PGE, NO, COX-2, iNOS, Macrophage
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